Epigenetic Aging Clock Predictions

GrimAge Mortality Predictor

The GrimAge measure of biological age has now been shown to strongly predict future healthspan and lifespan (Lu Horvath 2018, Li 2019). A 7.5 year acceleration of GrimAge relative to your chronological age equates to a doubling of mortality risk. Conversely, a 7.5 year reduction equates to approximately a 50% reduction in mortality risk.

Methylation Age

Developed by Steve Horvath with Ken Raj. This clock is a highly accurate predictor of chronological age, and as the name suggests, is based on use of both skin and blood cells. It is effective for in vitro cell culture studies and also can be used with buccal (cheek) swabs.

PhenoAge

Developed in Steve Horvath’s lab at UCLA by Morgan Levine. This clock enables prediction of healthspan and lifespan and has an analogous measure that can be used based on low-cost plasma biomarkers.

What can you do about your GrimAge score? Each component below is a separate GrimAge risk factor.

Each red line shows how you compare to the general population. As presented here, lower levels of each factor represent better scores, or lower risk.

The GrimAge measure enables surrogate markers of function based on biomarker data from large epidemiological clinical studies. Although these risk factors and your physiology overall is tightly interwoven, by focusing on the largest contributors to GrimAge acceleration we will be able to identify key areas for risk reduction. Note: The finalized DNAm GrimAge is based on transforming the raw variable into a distribution in units of year.

Age related predictions

Immune Cell Count Predictions

How does your immune system change with age?

Track how key immune cell subsets such as naive T cells and monocytes change over time. Each red line shows how your predicted immune cell levels compare to the general population.

DNA methylation enables a convenient way to also track immune system status, as it enables you to predict the levels of many important immune cell subsets that change with age. Your immune system is made up of many different types of specialized cells, including T cells that are educated in the thymus and that enable your body to fight cancer and infections. The immune system also ages, in a process known as immunosenescence, which is a major risk factor for near-term morbidity and mortality. For instance, in general, levels of naive CD4 and CD8 T cells decrease (shown above as: CD4.naive and CD8.naive). Certain cell types that are part of the innate immune system, such as monocytes (shown above as: Mono), typically increase with age and contribute to chronic inflammation in older individuals.

Blood cell type composition